| 18/08/2018 | 22:15 | FC Barcelona | 3 | 0 | Deportivo Alavés |
| 25/08/2018 | 22:15 | Real Valladolid CF | 0 | 1 | FC Barcelona |
| 02/09/2018 | 18:30 | FC Barcelona | 8 | 2 | SD Huesca |
| 15/09/2018 | 16:15 | Real Sociedad de Fútbol | 1 | 2 | FC Barcelona |
| 18/09/2018 | 18:55 | FC Barcelona | 4 | 0 | PSV |
| 23/09/2018 | 20:45 | FC Barcelona | 2 | 2 | Girona FC |
| 26/09/2018 | 20:00 | CD Leganés | 2 | 1 | FC Barcelona |
| 29/09/2018 | 16:15 | FC Barcelona | 1 | 1 | Athletic Club |
| 03/10/2018 | 21:00 | Tottenham Hotspur FC | 2 | 4 | FC Barcelona |
| 07/10/2018 | 20:45 | Valencia CF | 1 | 1 | FC Barcelona |
| 20/10/2018 | 20:45 | FC Barcelona | 4 | 2 | Sevilla FC |
| 24/10/2018 | 21:00 | FC Barcelona | 2 | 0 | FC Internazionale Milano |
| 28/10/2018 | 17:15 | FC Barcelona | 5 | 1 | Real Madrid CF |
| 03/11/2018 | 21:45 | Rayo Vallecano de Madrid | 2 | 3 | FC Barcelona |
| 06/11/2018 | 22:00 | FC Internazionale Milano | 1 | 1 | FC Barcelona |
| 11/11/2018 | 17:15 | FC Barcelona | 3 | 4 | Real Betis Balompié |
| 24/11/2018 | 21:45 | Club Atlético de Madrid | 1 | 1 | FC Barcelona |
| 28/11/2018 | 22:00 | PSV | 1 | 2 | FC Barcelona |
| 02/12/2018 | 19:30 | FC Barcelona | 2 | 0 | Villarreal CF |
| 08/12/2018 | 21:45 | RCD Espanyol de Barcelona | 0 | 4 | FC Barcelona |
| 11/12/2018 | 22:00 | FC Barcelona | 1 | 1 | Tottenham Hotspur FC |
| 16/12/2018 | 21:45 | Levante UD | 0 | 5 | FC Barcelona |
| 22/12/2018 | 19:30 | FC Barcelona | 2 | 0 | RC Celta de Vigo |
| 06/01/2019 | 21:45 | Getafe CF | 1 | 2 | FC Barcelona |
| 13/01/2019 | 19:30 | FC Barcelona | 3 | 0 | SD Eibar |
| 20/01/2019 | 21:45 | FC Barcelona | 3 | 1 | CD Leganés |
| 27/01/2019 | 17:15 | Girona FC | 0 | 2 | FC Barcelona |
| 02/02/2019 | 19:30 | FC Barcelona | 2 | 2 | Valencia CF |
| 10/02/2019 | 21:45 | Athletic Club | 0 | 0 | FC Barcelona |
| 16/02/2019 | 21:45 | FC Barcelona | 1 | 0 | Real Valladolid CF |
| 19/02/2019 | 22:00 | Olympique Lyonnais | 0 | 0 | FC Barcelona |
| 23/02/2019 | 17:15 | Sevilla FC | 2 | 4 | FC Barcelona |
| 02/03/2019 | 21:45 | Real Madrid CF | 0 | 1 | FC Barcelona |
| 09/03/2019 | 19:30 | FC Barcelona | 3 | 1 | Rayo Vallecano de Madrid |
| 13/03/2019 | 22:00 | FC Barcelona | 5 | 1 | Olympique Lyonnais |
| 17/03/2019 | 21:45 | Real Betis Balompié | 1 | 4 | FC Barcelona |
| 30/03/2019 | 17:15 | FC Barcelona | 2 | 0 | RCD Espanyol de Barcelona |
| 02/04/2019 | 21:30 | Villarreal CF | 4 | 4 | FC Barcelona |
| 06/04/2019 | 20:45 | FC Barcelona | 2 | 0 | Club Atlético de Madrid |
| 10/04/2019 | 21:00 | Manchester United FC | 0 | 1 | FC Barcelona |
| 13/04/2019 | 16:15 | SD Huesca | 0 | 0 | FC Barcelona |
| 16/04/2019 | 21:00 | FC Barcelona | 3 | 0 | Manchester United FC |
| 20/04/2019 | 20:45 | FC Barcelona | 2 | 1 | Real Sociedad de Fútbol |
| 23/04/2019 | 21:30 | Deportivo Alavés | 0 | 2 | FC Barcelona |
| 27/04/2019 | 20:45 | FC Barcelona | 1 | 0 | Levante UD |
| 01/05/2019 | 21:00 | FC Barcelona | 3 | 0 | Liverpool FC |
| 04/05/2019 | 20:45 | RC Celta de Vigo | 2 | 0 | FC Barcelona |
| 07/05/2019 | 21:00 | Liverpool FC | 4 | 0 | FC Barcelona |
| 12/05/2019 | 18:30 | FC Barcelona | 2 | 0 | Getafe CF |
| 19/05/2019 | 16:15 | SD Eibar | 2 | 2 | FC Barcelona |