Calendrier
| 27/09/2020 | 21:00 | FC Barcelona | 4 | 0 | Villarreal CF |
| 01/10/2020 | 21:30 | RC Celta de Vigo | 0 | 3 | FC Barcelona |
| 04/10/2020 | 21:00 | FC Barcelona | 1 | 1 | Sevilla FC |
| 17/10/2020 | 21:00 | Getafe CF | 1 | 0 | FC Barcelona |
| 20/10/2020 | 21:00 | FC Barcelona | 5 | 1 | Ferencvárosi TC |
| 24/10/2020 | 16:00 | FC Barcelona | 1 | 3 | Real Madrid CF |
| 28/10/2020 | 22:00 | Juventus FC | 0 | 2 | FC Barcelona |
| 31/10/2020 | 22:00 | Deportivo Alavés | 1 | 1 | FC Barcelona |
| 04/11/2020 | 22:00 | FC Barcelona | 2 | 1 | FK Dynamo Kyiv |
| 07/11/2020 | 17:15 | FC Barcelona | 5 | 2 | Real Betis Balompié |
| 21/11/2020 | 22:00 | Club Atlético de Madrid | 1 | 0 | FC Barcelona |
| 24/11/2020 | 22:00 | FK Dynamo Kyiv | 0 | 4 | FC Barcelona |
| 29/11/2020 | 15:00 | FC Barcelona | 4 | 0 | CA Osasuna |
| 02/12/2020 | 22:00 | Ferencvárosi TC | 0 | 3 | FC Barcelona |
| 05/12/2020 | 22:00 | Cádiz CF | 2 | 1 | FC Barcelona |
| 08/12/2020 | 22:00 | FC Barcelona | 0 | 3 | Juventus FC |
| 13/12/2020 | 22:00 | FC Barcelona | 1 | 0 | Levante UD |
| 16/12/2020 | 22:00 | FC Barcelona | 2 | 1 | Real Sociedad de Fútbol |
| 19/12/2020 | 17:15 | FC Barcelona | 2 | 2 | Valencia CF |
| 22/12/2020 | 23:00 | Real Valladolid CF | 0 | 3 | FC Barcelona |
| 29/12/2020 | 20:15 | FC Barcelona | 1 | 1 | SD Eibar |
| 03/01/2021 | 22:00 | SD Huesca | 0 | 1 | FC Barcelona |
| 06/01/2021 | 22:00 | Athletic Club | 2 | 3 | FC Barcelona |
| 09/01/2021 | 19:30 | Granada CF | 0 | 4 | FC Barcelona |
| 24/01/2021 | 17:15 | Elche CF | 0 | 2 | FC Barcelona |
| 31/01/2021 | 22:00 | FC Barcelona | 2 | 1 | Athletic Club |
| 07/02/2021 | 22:00 | Real Betis Balompié | 2 | 3 | FC Barcelona |
| 13/02/2021 | 22:00 | FC Barcelona | 5 | 1 | Deportivo Alavés |
| 16/02/2021 | 22:00 | FC Barcelona | 1 | 4 | Paris Saint-Germain FC |
| 21/02/2021 | 15:00 | FC Barcelona | 1 | 1 | Cádiz CF |
| 24/02/2021 | 20:00 | FC Barcelona | 3 | 0 | Elche CF |
| 27/02/2021 | 17:15 | Sevilla FC | 0 | 2 | FC Barcelona |
| 06/03/2021 | 22:00 | CA Osasuna | 0 | 2 | FC Barcelona |
| 10/03/2021 | 22:00 | Paris Saint-Germain FC | 1 | 1 | FC Barcelona |
| 15/03/2021 | 22:00 | FC Barcelona | 4 | 1 | SD Huesca |
| 21/03/2021 | 22:00 | Real Sociedad de Fútbol | 1 | 6 | FC Barcelona |
| 05/04/2021 | 21:00 | FC Barcelona | 1 | 0 | Real Valladolid CF |
| 10/04/2021 | 21:00 | Real Madrid CF | 2 | 1 | FC Barcelona |
| 22/04/2021 | 22:00 | FC Barcelona | | | Getafe CF |
| 25/04/2021 | 16:15 | Villarreal CF | | | FC Barcelona |
| 29/04/2021 | 02:00 | FC Barcelona | | | Granada CF |
| 02/05/2021 | 21:00 | Valencia CF | | | FC Barcelona |
| 10/05/2021 | 02:00 | FC Barcelona | | | Club Atlético de Madrid |
| 13/05/2021 | 02:00 | Levante UD | | | FC Barcelona |
| 17/05/2021 | 02:00 | FC Barcelona | | | RC Celta de Vigo |
| 24/05/2021 | 02:00 | SD Eibar | | | FC Barcelona |