Calendrier
| 20/08/2017 | 20:15 | FC Barcelona | 2 | 0 | Real Betis |
| 26/08/2017 | 18:15 | Deportivo Alavés | 0 | 2 | FC Barcelona |
| 09/09/2017 | 20:45 | FC Barcelona | 5 | 0 | RCD Espanyol |
| 12/09/2017 | 20:45 | FC Barcelona | 3 | 0 | Juventus Turin |
| 16/09/2017 | 16:15 | Getafe CF | 1 | 2 | FC Barcelona |
| 19/09/2017 | 22:00 | FC Barcelona | 6 | 1 | SD Eibar |
| 23/09/2017 | 20:45 | Girona FC | 0 | 3 | FC Barcelona |
| 27/09/2017 | 20:45 | Sporting CP | 0 | 1 | FC Barcelona |
| 01/10/2017 | 16:15 | FC Barcelona | 3 | 0 | UD Las Palmas |
| 14/10/2017 | 20:45 | Club Atlético de Madrid | 1 | 1 | FC Barcelona |
| 18/10/2017 | 20:45 | FC Barcelona | 3 | 1 | Olympiacos F.C. |
| 22/10/2017 | 20:45 | FC Barcelona | 2 | 0 | Málaga CF |
| 28/10/2017 | 20:45 | Athletic Club | 0 | 2 | FC Barcelona |
| 31/10/2017 | 22:45 | Olympiacos F.C. | 0 | 0 | FC Barcelona |
| 04/11/2017 | 22:45 | FC Barcelona | 2 | 1 | Sevilla FC |
| 18/11/2017 | 18:15 | CD Leganes | 0 | 3 | FC Barcelona |
| 22/11/2017 | 22:45 | Juventus Turin | 0 | 0 | FC Barcelona |
| 26/11/2017 | 22:45 | Valencia CF | 1 | 1 | FC Barcelona |
| 02/12/2017 | 15:00 | FC Barcelona | 2 | 2 | RC Celta de Vigo |
| 05/12/2017 | 22:45 | FC Barcelona | 2 | 0 | Sporting CP |
| 10/12/2017 | 22:45 | Villarreal CF | 0 | 2 | FC Barcelona |
| 17/12/2017 | 22:45 | FC Barcelona | 4 | 0 | RC Deportivo La Coruna |
| 23/12/2017 | 15:00 | Real Madrid CF | 0 | 3 | FC Barcelona |
| 07/01/2018 | 17:15 | FC Barcelona | 3 | 0 | Levante UD |
| 14/01/2018 | 21:45 | Real Sociedad de Fútbol | 2 | 4 | FC Barcelona |
| 21/01/2018 | 21:45 | Real Betis | 0 | 5 | FC Barcelona |
| 28/01/2018 | 21:45 | FC Barcelona | 2 | 1 | Deportivo Alavés |
| 04/02/2018 | 17:15 | RCD Espanyol | 1 | 1 | FC Barcelona |
| 11/02/2018 | 17:15 | FC Barcelona | 0 | 0 | Getafe CF |
| 17/02/2018 | 17:15 | SD Eibar | 0 | 2 | FC Barcelona |
| 20/02/2018 | 21:45 | Chelsea FC | 1 | 1 | FC Barcelona |
| 24/02/2018 | 21:45 | FC Barcelona | 6 | 1 | Girona FC |
| 01/03/2018 | 22:00 | UD Las Palmas | 1 | 1 | FC Barcelona |
| 04/03/2018 | 17:15 | FC Barcelona | 1 | 0 | Club Atlético de Madrid |
| 10/03/2018 | 21:45 | Málaga CF | 0 | 2 | FC Barcelona |
| 14/03/2018 | 21:45 | FC Barcelona | 3 | 0 | Chelsea FC |
| 18/03/2018 | 17:15 | FC Barcelona | 2 | 0 | Athletic Club |
| 31/03/2018 | 20:45 | Sevilla FC | 2 | 2 | FC Barcelona |
| 04/04/2018 | 20:45 | FC Barcelona | 4 | 1 | AS Roma |
| 07/04/2018 | 20:45 | FC Barcelona | 3 | 1 | CD Leganes |
| 10/04/2018 | 20:45 | AS Roma | 3 | 0 | FC Barcelona |
| 14/04/2018 | 16:15 | FC Barcelona | 2 | 1 | Valencia CF |
| 17/04/2018 | 21:00 | RC Celta de Vigo | 2 | 2 | FC Barcelona |
| 29/04/2018 | 20:45 | RC Deportivo La Coruna | | | FC Barcelona |
| 06/05/2018 | 00:00 | FC Barcelona | | | Real Madrid CF |
| 09/05/2018 | 00:00 | FC Barcelona | | | Villarreal CF |
| 13/05/2018 | 00:00 | Levante UD | | | FC Barcelona |
| 20/05/2018 | 00:00 | FC Barcelona | | | Real Sociedad de Fútbol |